IAO 0000115

Process(P1) directly negatively regulates process(P2) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P1 directly negatively regulates P2.

IAO 0000119

http://purl.obolibrary.org/obo/ro/docs/causal-relations

IAO 0000589

directly negatively regulates (process to process)

RO 0004050

http://purl.obolibrary.org/obo/RO_0002578

Parents