mature eosinophil
http://purl.obolibrary.org/obo/CL_0000041
A fully differentiated eosinophil, a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Cells are also differentiated from other granulocytes by a small nuclear-to-cytoplasm ratio (1:3). This cell type is CD49d-positive. [ GOC:tfm GOC:add GOC:dsd http://www.cap.org http://openisbn.com/search.php?q=0721601464&isbn=1/ ]
Synonyms: mature eosinocyte, mature eosinophil leucocyte, mature eosinophil leukocyte
Term info
human_reference_atlas
Eosinophils are CD125-positive (IL-5R), GM-CSFR-positive, IL-3R-positive, VLA4-positive. They can also express MHC Class I & II, CD4, CD9, CD11a, CD11b, CD11c, CD13, CD15, CD16, CD17, CD18, CD24, CD25,CD28, CD29, CD32, CD33, CD35, CD37, CD39, CD43, CD44, CD45, CD45RB, CD45RO, CD46, CD47, CD48, CD49d, CD49f, CD50, CD52, CD53, CD54, CD55, CD58, CD59, CD62L, CD63, CD65, CD66, CD69, CD71, CD76, CD80, CD81, CD82, CD86, CD87, CD88, CD89, CD92, CD95, CD97, CD98, CD99, CD100, CD101, CD116, CD117, CD119, CD120, CD123, CD124, CD125, CD131, CD137, CD139, CD148, CD149, CD151, CD153, CD156, CD162, CD161, CD162, CD165, CD174, CD182, CD183, CD191, CD192, CD193, CD196, CD213, IL9R, ad integrin, beta-7 integrin, FceRI, IL13Ra1, TGFbR, PAFR, LTB4R, C3aR, CystLT1R, CystLT2R, fMLPR, CRTH2 (PGD2 receptor), histamine 4R, IDO, KYN, PAR-2, Siglec-8, Siglec-10, LIR1, LIR2, LIR3, LIR7, TLR7, TLR8, and VLA-4. Eosinophils can also secrete CXCL1, eotaxin-1, GM-CSF, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, IL-16, IL-18, IFN-gamma, LTC4, MIP-1alpha, NGF, PAF, RANTES, substance P, TGF-alpha, TGF-beta, TNF-alpha, and VIP.
The status of eosinophils as true professional antigen presenting cells is unclear, despite their ability to present exogenous peptides and peptides processed from exogenous proteins (in certain studies) via MHC Class II and activate T cells. Per the equivalence axioms, 'eosinophil' is reasoned to be a subclass of 'professional antigen presenting cell', though the role of eosinophils as such in the body may be limited.
polymorphonuclear leucocyte, polymorphonuclear leukocyte
http://purl.obolibrary.org/obo/NCBITaxon_9606
Term relations
- eosinophil and has part some eosinophil peroxidase and has part some erythroid transcription factor and has part some endothelial transcription factor GATA-2 and has part some non-secretory ribonuclease and has part some eosinophil cationic protein and has part some eosinophil granule major basic protein and has part some (
nucleus and
bearer of some lobed) and has plasma membrane part some integrin alpha-4 and capable of some antigen processing and presentation of peptide antigen via MHC class II and capable of some leukotriene production involved in inflammatory response and capable of some respiratory burst
- professional antigen presenting cell
- eosinophil
- has plasma membrane part some integrin alpha-4
- has part some non-secretory ribonuclease
- develops from some band form eosinophil
- has part some (
nucleus and
bearer of some lobed) - has part some erythroid transcription factor
- has part some eosinophil cationic protein
- capable of some antigen processing and presentation of peptide antigen via MHC class II
- has part some eosinophil peroxidase
- has part some eosinophil granule major basic protein
- has part some endothelial transcription factor GATA-2
- capable of some leukotriene production involved in inflammatory response
- capable of some respiratory burst