mature neutrophil
http://purl.obolibrary.org/obo/CL_0000096
A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. They are produced in bone marrow at a rate of 5e10-10e10/day and have a half-life of 6-8 hours. Neutrophils are CD15-positive, CD16-positive, CD32-positive, CD43-positive, CD181-positive, and CD182-positive. [ MESH:D009504 GOC:tfm http://www.ncbi.nlm.nih.gov/pubmed/7880385 GOC:add http://www.cap.org http://www.ncbi.nlm.nih.gov/pubmed/11138776 http://www.ncbi.nlm.nih.gov/pubmed/12560239 http://www.ncbi.nlm.nih.gov/pubmed/15514007 ]
Synonyms: PMN, polynuclear neutrophilic leukocyte, mature neutrophilic leucocyte, mature neutrocyte, mature neutrophilic leukocyte, mature neutrophil leucocyte, mature neutrophil leukocyte, polymorphonuclear neutrophil, polynuclear neutrophilic leucocyte
Term info
- BTO:0003473
human_reference_atlas
Neutrophils are also capable of secreting GRO-alpha, IL-1beta, IL-1ra, IL-3, IL-12, IP-10, MIG, MIP-1alpha, MIP-1beta, TGF-beta, TNF-alpha, VEGF, and anti-microbial peptides. They can positively influence the chemotaxis of basophils, T-cells, monocytes, macrophages, dendritic cells, and other neutrophils. Neutrophils are also CD35-positive, CD64-positive, CD89-positive, CD184-positive, and fMLP receptor-positive Ly-6G-positive (mouse), TLR2-low, TLR4-low, and lineage-negative (CD2, CD3, CD5, CD9, CD19, CD36, CD49d, CD56, CD61, CD235a (glycophorin-A)).
polymorphonuclear leucocyte, poly, polymorphonuclear leukocyte
http://purl.obolibrary.org/obo/NCBITaxon_9606
Term relations
- neutrophil and has part some neutrophillic cytoplasm and has part some tertiary granule and has part some (
nucleus and
bearer of some lobed) and lacks_part some lactotransferrin and lacks_part some myeloperoxidase and lacks_part some myb proto-oncogene protein and has plasma membrane part some C-X-C chemokine receptor type 1 and has plasma membrane part some C-X-C chemokine receptor type 2 and has plasma membrane part some alpha-(1,3)-fucosyltransferase 4 and has plasma membrane part some low affinity immunoglobulin gamma Fc region receptor III and has plasma membrane part some leukosialin and has plasma membrane part some transcription factor PU.1 and has plasma membrane part some protein c-Fos and capable of some respiratory burst involved in inflammatory response and capable of some positive regulation of leukocyte chemotaxis and capable of some phagocytosis and capable of some interleukin-8 production
- phagocyte
- neutrophil
- has part some neutrophillic cytoplasm
- lacks_part some lactotransferrin
- has plasma membrane part some transcription factor PU.1
- capable of some positive regulation of leukocyte chemotaxis
- has part some (
nucleus and
bearer of some lobed) - has plasma membrane part some C-X-C chemokine receptor type 1
- lacks_part some myeloperoxidase
- has plasma membrane part some alpha-(1,3)-fucosyltransferase 4
- lacks_part some myb proto-oncogene protein
- has part some tertiary granule
- has plasma membrane part some C-X-C chemokine receptor type 2
- capable of some respiratory burst involved in inflammatory response
- has plasma membrane part some protein c-Fos
- capable of some interleukin-8 production
- has plasma membrane part some low affinity immunoglobulin gamma Fc region receptor III