microglial cell

http://purl.obolibrary.org/obo/CL_0000129

A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive. [ http://www.ncbi.nlm.nih.gov/pubmed/11517395 http://www.ncbi.nlm.nih.gov/pubmed/2089275 GOC:add http://www.ncbi.nlm.nih.gov/pubmed/16177057 http://openisbn.com/search.php?q=0721601464&isbn=1/ http://www.ncbi.nlm.nih.gov/pubmed/19461673 MESH:D017628 http://www.ncbi.nlm.nih.gov/pubmed/14561199 http://www.ncbi.nlm.nih.gov/pubmed/12430718 http://en.wikipedia.org/wiki/Microglia GOC:tfm GOC:dsd http://www.ncbi.nlm.nih.gov/pubmed/14612429 ]

Synonyms: hortega cells, microgliocyte, microglia, brain-resident macrophage

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Term history

Term info

database cross reference

BTO:0000962
BTO:0000078
FMA:54540
FMA:54539

Subsets

human_reference_atlas

comment

Unlike macroglial cells, microglial cells arise from hematopoietic stem cells in the yolk sac during early embryogenesis that populate the central nervous system. They derive from embryonic mesoderm and are not from neuroectoderm where glioblast develops from. Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive.

has related synonym

MF.microglia.CNS

has broad synonym

brain macrophage

present in taxon

http://purl.obolibrary.org/obo/NCBITaxon_9606