mesenchymal stem cell
http://purl.obolibrary.org/obo/CL_0000134
A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs. [ http://en.wikipedia.org/wiki/Mesenchymal_stem_cell http://www.ncbi.nlm.nih.gov/pubmed/10102814 http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells http://flybase.org/reports/ma.html GOC:dsd http://www.ncbi.nlm.nih.gov/sites/entrez?db=pmc&cmd=search&term=PMC2613570 http://www.ncbi.nlm.nih.gov/pubmed/17986482 http://www.ncbi.nlm.nih.gov/pubmed/19960544 http://www.ncbi.nlm.nih.gov/pubmed/16923606 ]
Term info
- BTO:0002625
- FMA:70546
- BTO:0003298
Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.
mesenchymal stem cell, mesenchymal progenitor cells, mesenchymal stromal cells, mesenchymal precursor cell, stem cells, mesenchymal, CFU-F, mesenchymal stromal cell, MSC
CL:0002452
bone marrow stromal cells, BMSC, colony-forming unit-fibroblast, marrow stromal cells
cell
http://purl.obolibrary.org/obo/uberon.owl, http://purl.obolibrary.org/obo/cl.owl
Mesenchymal cell
https://github.com/obophenotype/cell-ontology/issues/474