macrophage
http://purl.obolibrary.org/obo/CL_0000235
A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells. [ GOC:add GOC:tfm http://www.ncbi.nlm.nih.gov/pubmed/1919437 http://www.ncbi.nlm.nih.gov/pubmed/16213494 http://purl.obolibrary.org/obo/go/references/0000031 ]
Synonyms: histiocyte
Term info
- FMA:63261
- CALOHA:TS-0587
- BTO:0000801
- FMA:83585
- MESH:D008264
human_reference_atlas
Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid.
Histiocyte, Macrophage
http://purl.obolibrary.org/obo/NCBITaxon_9606
Term relations
- myeloid leukocyte and capable of some antigen processing and presentation of peptide or polysaccharide antigen via MHC class II and capable of some phagocytosis and capable of some pseudopodium organization
- myeloid leukocyte
- professional antigen presenting cell
- phagocyte
- develops from some monocyte
- capable of some pseudopodium organization