keratinocyte
http://purl.obolibrary.org/obo/CL_0000312
An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell. [ http://en.wikipedia.org/wiki/Keratinocyte http://www.ncbi.nlm.nih.gov/pubmed/15749908 http://www.ncbi.nlm.nih.gov/pubmed/19727116 GOC:dsd MESH:D015603 http://www.ncbi.nlm.nih.gov/pubmed/15582983 ]
Synonyms: malpighian cell, keratinized cell of epidermis
Term info
- FMA:62879
- CALOHA:TS-0500
- BTO:0000667
human_reference_atlas
Keratinocytes are reportedly CDw210a-negative, CDw210b-positive, CD281-positive, CD282-positive, CD285-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive.
CL:0002185
Keratinized cell of epidermis
http://purl.obolibrary.org/obo/NCBITaxon_9606
Term relations
- keratinizing barrier epithelial cell
- epidermal cell
- part of some skin epidermis
- capable of some antimicrobial peptide production
- capable of some antimicrobial peptide secretion
- capable of some positive regulation of neutrophil chemotaxis