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mucosal type mast cell

^ http://purl.obolibrary.org/obo/CL_0000485


Mast cell subtype that contains only the serine protease trypase in its granules. These cells are primarily found in mucosal tissue, such as intestinal mucosa and alveoli. They depend upon T-cells for development of phenotype. [ http://www.ncbi.nlm.nih.gov/pubmed/9354811 http://www.ncbi.nlm.nih.gov/pubmed/19923473 GOC:add GOC:dsd ]

Synonyms: T mast cells, MC(T), MCT

Term info

Subsets

human_reference_atlas

comment

They are CD88-negative. The cytoplasmic granules contain low levels of histamine and high levels of chondroitin sulfate (mouse) or major neutral proteases and tryptase (humans). Additionally, they can produce leukotrienes (LTC4), IL-5, IL-6, and low levels of IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype.

present in taxon

http://purl.obolibrary.org/obo/NCBITaxon_9606