An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix. [ MESH:D019879 GOC:tfm http://openisbn.com/search.php?q=0517223651&isbn=1/ http://www.ncbi.nlm.nih.gov/pubmed/29184701 http://www.ncbi.nlm.nih.gov/pubmed/32308658 ]