neutrophilic promyelocyte
http://purl.obolibrary.org/obo/CL_0000564
A promyelocyte committed to the neutrophil lineage. This cell type is GATA-1-positive, C/EBPa-positive, AML-1-positive, MPO-positive, has low expression of PU.1 transcription factor and lacks lactotransferrin expression. [ GOC:dsd http://www.ncbi.nlm.nih.gov/pubmed/12560239 http://www.ncbi.nlm.nih.gov/pubmed/15514007 GOC:add GOC:tfm http://openisbn.com/search.php?q=0721601464&isbn=1/ ]
Synonyms: neutrophilic premyelocyte, neutrophilic progranulocyte
Term info
- FMA:84196
These cells are CD11b-negative, CD15-positive, CD16-negative, CD49d-positive, CD68-positive, CD35-negative, and fMLP receptor-negative. They are found in the Band 3 fraction.
Term relations
- promyelocyte and has part some transcription factor PU.1 and has part some CCAAT/enhancer-binding protein alpha and has part some erythroid transcription factor and has part some myeloperoxidase and has part some runt-related transcription factor 1 and lacks_part some lactotransferrin and capable of some neutrophil differentiation
- promyelocyte
- neutrophil progenitor cell
- has part some runt-related transcription factor 1
- lacks_part some lactotransferrin
- has part some myeloperoxidase
- has part some transcription factor PU.1
- develops from some neutrophilic myeloblast
- has part some CCAAT/enhancer-binding protein alpha
- has part some erythroid transcription factor