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neutrophilic metamyelocyte

^ http://purl.obolibrary.org/obo/CL_0000582


A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and the band form neutrophil. The protein synthesis seen in earlier stages decreases or stops; the nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare; and the cytoplasm becomes amphophilic like that of a mature granulocyte. This cell type is integrin alpha-M-positive, CD13-negative, CD15-positive, CD16-positive, CD33-positive, CD24-positive, fMLP receptor-negative and has expression of C/EBP-a, C/EBP-e, PU.1 transcription factor, lactotransferrin, myeloperoxidase and neutrophil gelatinase associated lipocalin. [ http://www.cap.org GOC:add GOC:dsd GOC:tfm http://www.ncbi.nlm.nih.gov/pubmed/12560239 http://www.ncbi.nlm.nih.gov/pubmed/15514007 http://openisbn.com/search.php?q=0721601464&isbn=1/ http://www.ncbi.nlm.nih.gov/pubmed/10618520 ]

Synonyms: juvenile neutrophil

Term info

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These cells are also CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction.

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