basophil progenitor cell
http://purl.obolibrary.org/obo/CL_0000613
A progenitor cell committed to the basophil lineage. This cell lacks hematopoietic lineage markers (lin-negative) and is CD34-positive, T1/ST2-low, CD117-negative, and FceRIa-high. This cell also expresses Gata-1, Gata-2 and C/EBPa. [ GOC:dsd http://www.ncbi.nlm.nih.gov/sites/entrez?db=pmc&cmd=search&term=PMC1312421 http://www.copewithcytokines.de GOC:add ]
Synonyms: BaP
Term info
BaP are also CD13-low and integrin beta-7-low. They are lin-negative (CD2, CD3e, CD4, CD5, CD8, CD11b, CD14, CD19, CD20, ly6g, ly76, and NCAM-1). They also lack expression of mast cell protease 1 (MCP-1) and microphthalmia-associated transcription factor (mitf).
CFU-Bas, colony forming unit basophil, basophilic stem cell
Term relations
- granulocytopoietic cell and has part some CCAAT/enhancer-binding protein alpha and has part some erythroid transcription factor and has part some endothelial transcription factor GATA-2 and lacks_plasma_membrane_part some CD19 molecule and lacks_plasma_membrane_part some CD4 molecule and lacks_plasma_membrane_part some integrin alpha-M and lacks_plasma_membrane_part some CD3 epsilon and lacks_plasma_membrane_part some neural cell adhesion molecule 1 and lacks_plasma_membrane_part some CD2 molecule and lacks_plasma_membrane_part some T-cell surface glycoprotein CD8 alpha chain and lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1 and lacks_plasma_membrane_part some T-cell surface glycoprotein CD5 and lacks_plasma_membrane_part some CD14 molecule and lacks_plasma_membrane_part some mast/stem cell growth factor receptor and lacks_plasma_membrane_part some lymphocyte antigen 6G and lacks_plasma_membrane_part some lymphocyte antigen 76 (mouse) and capable of some basophil differentiation and has high plasma membrane amount some high affinity immunoglobulin epsilon receptor subunit alpha and has low plasma membrane amount some transmembrane emp24 domain-containing protein 1
- granulocytopoietic cell
- protein-containing material entity
- myeloid cell
- lacks_plasma_membrane_part some lymphocyte antigen 6G
- lacks_plasma_membrane_part some integrin alpha-M
- lacks_plasma_membrane_part some lymphocyte antigen 76 (mouse)
- has part some CCAAT/enhancer-binding protein alpha
- lacks_plasma_membrane_part some CD3 epsilon
- has part some erythroid transcription factor
- lacks_plasma_membrane_part some CD2 molecule
- has high plasma membrane amount some high affinity immunoglobulin epsilon receptor subunit alpha
- lacks_plasma_membrane_part some mast/stem cell growth factor receptor
- develops from some basophil mast progenitor cell
- capable of some basophil differentiation
- lacks_plasma_membrane_part some T-cell surface glycoprotein CD5
- lacks_plasma_membrane_part some CD14 molecule
- lacks_plasma_membrane_part some T-cell surface glycoprotein CD8 alpha chain
- lacks_plasma_membrane_part some CD19 molecule
- lacks_plasma_membrane_part some neural cell adhesion molecule 1
- has low plasma membrane amount some transmembrane emp24 domain-containing protein 1
- lacks_plasma_membrane_part some CD4 molecule
- lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1
- has part some endothelial transcription factor GATA-2