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hepatic stellate cell

^ http://purl.obolibrary.org/obo/CL_0000632

A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver. [ http://www.ncbi.nlm.nih.gov/pubmed/12808230 http://www.ncbi.nlm.nih.gov/pubmed/9302568 http://www.ncbi.nlm.nih.gov/pubmed/18222966 GOC:dsd http://en.wikipedia.org/wiki/Hepatic_stellate_cell MESH:D055166 http://www.ncbi.nlm.nih.gov/pubmed/17239632 ]

Synonyms: hepatic perisinusoidal cell, Ito cell, perisinusoidal cell

Term info

database cross reference
  • BTO:0002741
  • CALOHA:TS-0452
  • FMA:67763
Subsets

human_reference_atlas

comment

Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen.

has related synonym

lipocyte, vitamin A-storing cells, fat-storing cell

present in taxon

http://purl.obolibrary.org/obo/NCBITaxon_9606