multinucleated giant cell
http://purl.obolibrary.org/obo/CL_0000647
A phagocytic cell formed by the fusion of macrophages, occurs in chronic inflammatory responses to persistent microorganism such as M.tuberculosis, component of granulomas. Sometimes used to refer to megakaryocytes. [ GOC:add http://openisbn.com/search.php?q=0702024783&isbn=1/ GOC:tfm http://openisbn.com/search.php?q=0702022918&isbn=1/ ]
Synonyms: syncytial giant cell, multinucleate giant cell, macrophage polykaryon, foreign body giant cell, Langerhans giant cell
Term info
- MESH:D015726
- BTO:0003107
- FMA:83035
Role or process: Chronic infection, granulomatous inflammation. Consider also megakaryocyte (CL:0000556) as sometimes multinucleated giant cell is used to refer to this.
Term relations
- myeloid leukocyte and bearer of some multinucleate and participates_in some granuloma formation and participates_in some chronic inflammatory response
- myeloid leukocyte
- multinucleate cell
- develops from some macrophage
- participates_in some granuloma formation
- participates_in some chronic inflammatory response