basophil
http://purl.obolibrary.org/obo/CL_0000767
Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive. [ GOC:dsd GOC:add MESH:D001491 http://www.ncbi.nlm.nih.gov/pubmed/9933081 GOC:amm http://www.ncbi.nlm.nih.gov/sites/entrez?db=pmc&cmd=search&term=PMC2626675 http://www.ncbi.nlm.nih.gov/pubmed/11927641 http://openisbn.com/search.php?q=0721601464&isbn=1/ http://www.ncbi.nlm.nih.gov/pubmed/19741522 GOC:tfm http://www.ncbi.nlm.nih.gov/pubmed/21236338 ]
Synonyms: basophilic leucocyte, basophilic leukocyte
Term info
- FMA:62862
- CALOHA:TS-0073
- BTO:0000129
human_reference_atlas
Matures in the bone marrow and account for <1% of leukocytes in the peripheral blood, spleen, and bone marrow. Basophils are described as being CD11a-positive, CD11b-positive, CD13-positive, CD15-positive, CD18-positive, CD21-positive, CD25-positive, CD29-positive, CD35-positive, CD40-positive, CD40L-positive, CD44-positive, CD45R-negative, CD46-positive, CD49a-positive, CD49b-positive, CD49d-positive, CD55-positive, CD59-positive, CD62L-positive, CD63-positive, CD69-positive, CD90-negative, CD116-positive, CD117-negative, CD124-positive, CD125-positive, CD131-positive, CD161-positive, CD184-positive, CD191-positive, CD192-positive, CD197-positive, CD200R3-positive, CD218-positive, CD282-positive, CD284-positive, CD289-positive, CD290-positive, CD294-positive, natural killer cell receptor 2B4-positive, smad1-positive, CD3-negative, CD4-negative, CD7-negative, CD8-negative, CD14-negative, CD15-negative, CD16-negative, CD19-negative, CD20-negative, CD34-negative, CD36-negative, CD45R-negative, CD56-negative, CD57-negative, CD235a-negative, and GR1-negative. Transcription factors- GATA1-positive, PU.1-positive.
polymorphonuclear leucocyte, polymorphonuclear leukocyte
http://purl.obolibrary.org/obo/NCBITaxon_9606
Term relations
- granulocyte and has plasma membrane part some ectonucleotide pyrophosphatase/phosphodiesterase family member 3 and has plasma membrane part some tumor necrosis factor ligand superfamily member 5 and has high plasma membrane amount some C-C chemokine receptor type 3 and has high plasma membrane amount some interleukin-3 receptor class 2 alpha chain and has high plasma membrane amount some high affinity immunoglobulin epsilon receptor subunit alpha
- granulocyte
- has high plasma membrane amount some C-C chemokine receptor type 3
- has high plasma membrane amount some interleukin-3 receptor class 2 alpha chain
- has plasma membrane part some ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- has high plasma membrane amount some high affinity immunoglobulin epsilon receptor subunit alpha
- has plasma membrane part some tumor necrosis factor ligand superfamily member 5