immature B cell
http://purl.obolibrary.org/obo/CL_0000816
An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation. [ GOC:tfm http://openisbn.com/search.php?q=0781735149&isbn=1/ GOC:dsd http://www.ncbi.nlm.nih.gov/pubmed/20081059 http://www.ncbi.nlm.nih.gov/pubmed/20839338 GOC:rhs GOC:add http://purl.obolibrary.org/obo/go/references/0000031 ]
Synonyms: newly formed B cell, immature B lymphocyte, immature B-cell, immature B-lymphocyte
Term info
human_reference_atlas
Immature B cells are also reportedly CD5-positive, CD10-positive, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD24-positive, CD25-negative, CD27-negative, CD34-negative, CD38-positive, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD79a-positive, CD80-negative, CD81-positive, CD86-negative, CD95-negative, CD127-negative, CD138-negative, CD185-positive, CD196-positive, MHCII/HLA-DR-positive, RAG-positive, TdT-negative, Vpre-B-negative, and preBCR-negative. Transcription factors expressed: Pax5-positive.
http://purl.obolibrary.org/obo/NCBITaxon_9606
Term relations
- B cell, CD19-positive and has plasma membrane part some IgM immunoglobulin complex and has plasma membrane part some membrane-spanning 4-domains subfamily A member 1 and has_not_completed some isotype switching and lacks_plasma_membrane_part some IgD immunoglobulin complex
- B cell, CD19-positive and has_not_completed some isotype switching and lacks_plasma_membrane_part some IgD immunoglobulin complex and has plasma membrane part some IgM immunoglobulin complex and has plasma membrane part some membrane-spanning 4-domains subfamily A member 1
- B cell, CD19-positive
- has_not_completed some isotype switching
- lacks_plasma_membrane_part some IgD immunoglobulin complex
- has_not_completed some isotype switching
- lacks_plasma_membrane_part some IgD immunoglobulin complex
- has plasma membrane part some IgM immunoglobulin complex
- has plasma membrane part some membrane-spanning 4-domains subfamily A member 1
- develops from some small pre-B-II cell