mast cell progenitor
http://purl.obolibrary.org/obo/CL_0000831
A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative. [ http://www.copewithcytokines.de http://www.ncbi.nlm.nih.gov/sites/entrez?db=pmc&cmd=search&term=PMC1183570 GOC:add http://www.ncbi.nlm.nih.gov/sites/entrez?db=pmc&cmd=search&term=PMC1312421 http://www.ncbi.nlm.nih.gov/pubmed/9354811 http://www.ncbi.nlm.nih.gov/pubmed/8629001 GOC:dsd ]
Synonyms: MCP
Term info
MCP are CD16-positive, CD32-positive, CD34-positive, CD45-positive, integrin beta-7-positive, and lin-negative (CD2, CD3e, CD4, CD5, CD8a, CD14, CD19, CD20, CD27, integrin alpha-M, ly6c, ly6g, NCAM-1, and ter119). These cells also express the transcription factors GATA-1, GATA-2, and MITF, but not C/EBPa.
colony forming unit mast cell, CFU-MC, CFU-Mast
Term relations
- myeloid lineage restricted progenitor cell and has part some erythroid transcription factor and has part some endothelial transcription factor GATA-2 and lacks_part some CCAAT/enhancer-binding protein alpha and lacks_plasma_membrane_part some CD19 molecule and lacks_plasma_membrane_part some CD4 molecule and lacks_plasma_membrane_part some integrin alpha-M and lacks_plasma_membrane_part some CD3 epsilon and lacks_plasma_membrane_part some neural cell adhesion molecule 1 and lacks_plasma_membrane_part some CD2 molecule and lacks_plasma_membrane_part some T-cell surface glycoprotein CD8 alpha chain and lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1 and lacks_plasma_membrane_part some T-cell surface glycoprotein CD5 and lacks_plasma_membrane_part some CD14 molecule and lacks_plasma_membrane_part some CD27 molecule and lacks_plasma_membrane_part some lymphocyte antigen 6G and lacks_plasma_membrane_part some lymphocyte antigen 6A-2/6E-1 and lacks_plasma_membrane_part some lymphocyte antigen 6C2 and lacks_plasma_membrane_part some lymphocyte antigen 76 (mouse) and has plasma membrane part some CD9 molecule and has plasma membrane part some transmembrane emp24 domain-containing protein 1 and capable of some mast cell differentiation and has high plasma membrane amount some integrin beta-7 and has low plasma membrane amount some mast/stem cell growth factor receptor and has low plasma membrane amount some high affinity immunoglobulin epsilon receptor subunit alpha
- protein-containing material entity
- myeloid cell
- myeloid lineage restricted progenitor cell
- lacks_plasma_membrane_part some lymphocyte antigen 76 (mouse)
- has plasma membrane part some CD9 molecule
- capable of some mast cell differentiation
- has low plasma membrane amount some mast/stem cell growth factor receptor
- has part some erythroid transcription factor
- lacks_plasma_membrane_part some CD2 molecule
- develops from some basophil mast progenitor cell
- has low plasma membrane amount some high affinity immunoglobulin epsilon receptor subunit alpha
- lacks_plasma_membrane_part some T-cell surface glycoprotein CD8 alpha chain
- lacks_plasma_membrane_part some lymphocyte antigen 6A-2/6E-1
- lacks_part some CCAAT/enhancer-binding protein alpha
- has plasma membrane part some transmembrane emp24 domain-containing protein 1
- lacks_plasma_membrane_part some CD4 molecule
- lacks_plasma_membrane_part some lymphocyte antigen 6G
- lacks_plasma_membrane_part some lymphocyte antigen 6C2
- lacks_plasma_membrane_part some integrin alpha-M
- lacks_plasma_membrane_part some CD27 molecule
- has high plasma membrane amount some integrin beta-7
- lacks_plasma_membrane_part some CD3 epsilon
- lacks_plasma_membrane_part some T-cell surface glycoprotein CD5
- lacks_plasma_membrane_part some CD14 molecule
- lacks_plasma_membrane_part some CD19 molecule
- lacks_plasma_membrane_part some neural cell adhesion molecule 1
- lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1
- has part some endothelial transcription factor GATA-2