germinal center B cell
http://purl.obolibrary.org/obo/CL_0000844
A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation. [ http://www.ncbi.nlm.nih.gov/pubmed/20933013 GOC:add GOC:tfm http://www.ncbi.nlm.nih.gov/pubmed/19447676 http://openisbn.com/search.php?q=0781735149&isbn=1/ GOC:dsd ]
Synonyms: germinal center B-lymphocyte, germinal center B lymphocyte, GC B-lymphocyte, GC B cell, germinal center B-cell, GC B-cell, GC B lymphocyte
Term info
human_reference_atlas
Germinal center B cells are also reportedly CD10-positive, CD19-positive, CD20-positive, CD38-positive, CD44-low, CD45-positive, CD48-positive, CD95-positive, CD352-positive, and HLA-DR-positive. Transcription factors: BCL6-positive, Ets1-positive, IRF8-positive, MTA3-positive, OBF1-positive, PAX5-positive, SpiB-positive, and STAT3-positive.
http://purl.obolibrary.org/obo/NCBITaxon_9606
Term relations
- mature B cell and part of some secondary nodular lymphoid tissue and has plasma membrane part some membrane-spanning 4-domains subfamily A member 1