myeloid suppressor cell
http://purl.obolibrary.org/obo/CL_0000889
An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive. [ http://www.ncbi.nlm.nih.gov/pubmed/17016554 http://www.ncbi.nlm.nih.gov/pubmed/16168663 http://www.ncbi.nlm.nih.gov/pubmed/17016559 http://purl.obolibrary.org/obo/go/references/0000031 GOC:add GOC:ana ]
Term info
Markers: Mouse: CD11b+GR1+CD31+; Human: CD34+ CD33+CD15-CD13+. (According to some reports in humans these cells are iNOS+ARG1+IL13+IFNg+); location: In cancerous tissue; in the blood and lymphoid organs in sepsis.
Term relations
- myeloid leukocyte and bearer of some immature and has plasma membrane part some receptor-type tyrosine-protein phosphatase C and has plasma membrane part some integrin alpha-M and capable of some negative regulation of immune response