naive thymus-derived CD8-positive, alpha-beta T cell
http://purl.obolibrary.org/obo/CL_0000900
A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low. [ http://purl.obolibrary.org/obo/go/references/0000031 GOC:tfm http://openisbn.com/search.php?q=0781735149&isbn=1/ http://www.ncbi.nlm.nih.gov/pubmed/22343568 http://www.immgen.org/index_content.html GOC:add ]
Synonyms: naive thymus-dervied CD8-positive, alpha-beta T-cell, naive thymus-dervied CD8-positive, alpha-beta T-lymphocyte, naive thymus-dervied CD8-positive, alpha-beta T lymphocyte
Term info
human_reference_atlas
This cell traffics in secondary lymphoid organs and blood. This cell type is compatible with the HIPC Lyoplate markers for 'naive CD8+ T cell', but includes additional markers known to be expressed on naive CD8+ T cells.
naive CD8+ T cell
T.8Nve.Sp
http://purl.obolibrary.org/obo/NCBITaxon_9606
Term relations
- CD8-positive, alpha-beta T cell and lacks_plasma_membrane_part some interleukin-2 receptor subunit alpha and has plasma membrane part some receptor-type tyrosine-protein phosphatase C isoform CD45RA and has plasma membrane part some C-C chemokine receptor type 7 and has plasma membrane part some interleukin-7 receptor subunit alpha and has high plasma membrane amount some L-selectin and has low plasma membrane amount some CD44 molecule
- naive T cell
- CD8-positive, alpha-beta T cell
- develops from some mature CD8 single-positive thymocyte
- lacks_plasma_membrane_part some interleukin-2 receptor subunit alpha