regulatory B cell
http://purl.obolibrary.org/obo/CL_0000969
A mature B cell that has the phenotype CD1d-positive and expresses interleukin-10. This cell type has been associated with suppression of chronic inflammatory responses and T cell responses. [ GOC:msz GOC:tfm MESH:D060151 http://www.ncbi.nlm.nih.gov/pubmed/20224569 GOC:dsd http://purl.obolibrary.org/obo/go/references/0000031 http://www.ncbi.nlm.nih.gov/pubmed/11869683 http://www.ncbi.nlm.nih.gov/pubmed/18482568 http://www.ncbi.nlm.nih.gov/pubmed/20809522 ]
Synonyms: B(reg), regulatory B-lymphocyte, B10 cell, regulatory B-cell, regulatory B lymphocyte, Breg
Term info
Regulatory B cells reportedly represent 1-2% of the spleen and 7-8% of the peritoneal B220-positive cells in mice. They are also found in the bone marrow, lymph node, and blood of mice. These cells are also reportedly capable of secreting IL-10 and are reportedly CD5-positive, CD21-positive, CD24-positive, CD93-negative, B220-positive, IgM-positive, and IgD-positive.
Term relations
- mature B cell and has plasma membrane part some membrane-spanning 4-domains subfamily A member 1 and has plasma membrane part some antigen-presenting glycoprotein CD1d and capable of some interleukin-10 production and capable of some negative regulation of immune response