T follicular helper cell
http://purl.obolibrary.org/obo/CL_0002038
A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production. [ http://www.ncbi.nlm.nih.gov/pubmed/19855402 http://www.ncbi.nlm.nih.gov/pubmed/22043829 GOC:tfm http://www.ncbi.nlm.nih.gov/pubmed/20107805 ]
Synonyms: T(FH), Tfh
Term info
human_reference_atlas
https://orcid.org/0000-0003-1980-3228
2009-10-29T04:01:27Z
follicular helper T-cell, follicular T cell, follicular B helper T cell, follicular T-helper cell, follicular T-cell, follicular helper T cell
http://purl.obolibrary.org/obo/NCBITaxon_9606
Term relations
- CD4-positive helper T cell and has part some B-cell lymphoma 6 protein and lacks_plasma_membrane_part some C-C chemokine receptor type 7 and has plasma membrane part some C-X-C chemokine receptor type 5 and has plasma membrane part some inducible T-cell costimulator and has plasma membrane part some programmed cell death protein 1 and capable of some positive regulation of isotype switching and capable of some GO_0051024
- CD4-positive helper T cell
- capable of some GO_0051024
- has plasma membrane part some programmed cell death protein 1
- capable of some positive regulation of isotype switching
- has plasma membrane part some inducible T-cell costimulator
- has part some B-cell lymphoma 6 protein
- lacks_plasma_membrane_part some C-C chemokine receptor type 7
- has plasma membrane part some C-X-C chemokine receptor type 5