JSON

hepatic oval stem cell

^ http://purl.obolibrary.org/obo/CL_0002196

A transient hepatic stem cell observed after liver injury with a high nuclear to cytoplasm ratio that can differentiate into mature hepatocytes and bile duct cells. Arises from more than one tissue. [ http://www.ncbi.nlm.nih.gov/pubmed/17901986 ]

Synonyms: hepatic oval cell, hepatic progenitor cell, liver progenitor cell

Term info

database cross reference
  • FMA:86576
  • BTO:0004270
Subsets

human_reference_atlas

contributor

https://orcid.org/0000-0003-1980-3228

creation date

2010-08-30T02:01:49Z

is negative form of

Liver progenitor cells have been variously named in rodent and human studies as oval cells, hepatic progenitor cells, liver stem cells, ductular reactions, or atypical ductular cells. They were first described as oval cells in rats due to their large nuclear-to-cytoplasm ratio and oval-shaped nuclei. On the difference between 'hepatic liver stem cells' (HLSC) and 'oval cells': "... unlike a well-known hepatic progenitor cell population, known as oval cells in rodents, HLSCs do not express CK-7, CK-19, c-kit, CD133 and alpha-smooth muscle actin (α-SMA) (Gaudio et al., 2009)".

present in taxon

http://purl.obolibrary.org/obo/NCBITaxon_9606

Term relations

Subclass of: