CD141-positive myeloid dendritic cell

http://purl.obolibrary.org/obo/CL_0002394

A myeloid dendritic cell found in the blood, lymph nodes, tonsil, bone marrow, and spleen that is CD141-positive (BDCA-3), XCR1-positive, and Clec9A-positive. This cell-type can cross-present antigen to CD8-positive T cells and can produce inteferon-beta. [ http://www.ncbi.nlm.nih.gov/sites/entrez?db=pmc&cmd=search&term=PMC2882828 GOC:dsd http://www.ncbi.nlm.nih.gov/pubmed/17332250 http://www.ncbi.nlm.nih.gov/sites/entrez?db=pmc&cmd=search&term=PMC2882837 GOC:tfm http://www.ncbi.nlm.nih.gov/pubmed/20628149 ]

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Term history

Term info

Subsets

human_reference_atlas

comment

Markers are found in human cells. Normally they represent 3-5% of peripheral blood mDCs (human). These cells express high levels of CD283 (TLR3), are capable of producing IL-12p70 and IFN-beta upon stimulation, and inducing a TH1 response [PMCID:PMC2882828]. They are also Necl2-positive. May be human equivalent of murine CD8alpha-positive DCs.

contributor

https://orcid.org/0000-0003-1980-3228

creation date

2010-10-04T02:38:58Z

present in taxon

http://purl.obolibrary.org/obo/NCBITaxon_9606

Term relations

Equivalent to:

myeloid dendritic cell and has plasma membrane part some thrombomodulin and capable of some positive regulation of T-helper 1 type immune response and capable of some type I interferon production and capable of some antigen processing and presentation of exogenous peptide antigen via MHC class I

Subclass of: