mature microglial cell
http://purl.obolibrary.org/obo/CL_0002629
A mature microglial cell that has changed shape to an amoeboid morphology and is capable of cytokine production and antigen presentation. [ GOC:dsd http://www.ncbi.nlm.nih.gov/pubmed/15246020 http://www.ncbi.nlm.nih.gov/pubmed/18396103 http://www.ncbi.nlm.nih.gov/pubmed/11517395 http://www.ncbi.nlm.nih.gov/pubmed/16177057 http://www.ncbi.nlm.nih.gov/pubmed/14612429 http://www.ncbi.nlm.nih.gov/pubmed/20021364 ]
Synonyms: reactive microglia, mature microglia, activated microglia
Term info
Mature microglia are reportedly CCR2-positive, CD4-positive, CD9-positive, CD11a-positive, CD11b-positive, CD11c-positive, CD13-positive, CD16-positive, CDw17-positive, CD18-positive, CD21-positive, CD26-negative, CD32-positive, CD35-positive, CD36-positive, CD40-positive, CD44-positive, CD45-positive, CD53-positive, CD54-positive, CD56-negative, CD58-positive, CD63-positive, CD64-positive, CD66-positive, CD80-positive, CD86-positive, CD87-positive, CD92-positive, CD106-positive, CD107a-positive, CD147-positive, CD155-positive, CD162-positive, CD163-positive, CD171-negative, CD200R-positive, CXCR3-positive, CX3CR1-positive, fibronectin-positive, GD3-positive, GLUT1-positive, GLUT3-negative, GLUT5-positive, MHCI-positive, MHCII-positive, P2X4-positive, RFD7-negative, RGS5-negative, alpha-SMA-negative, vimentin-positive, and vwf-negative. Mature microglia are capable of producing BDNF, CCL3, CCL5, CCL7, CCL8, CCL9, CCL19, CCL20,CD40L, CSF, CXCL1, CXCL2, CXCL4, CXCL5, CXCL8, CXCL9, CXCL10, glutamate, IL-1beta, IL-1ra, IL-3, IL-6, IL-10, IL-12, LT, MMP-2, MMP-9, NGF, nitric oxide, ROS, TGF-beta, TNF-alpha.
Term relations
- microglial cell and capable of some cytokine production and capable of some respiratory burst involved in inflammatory response and capable of some nitric oxide production involved in inflammatory response and capable of some phagocytosis and capable of some antigen processing and presentation