transmembrane receptor protein tyrosine kinase activity
http://purl.obolibrary.org/obo/GO_0004714
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. [ GOC:mah http://www.expasy.org/enzyme/2.7.10.1 ]
Term info
- Reactome:R-HSA-8950591 (JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated)
- Reactome:R-HSA-198295 (TRKA phosphorylates IRS)
- Reactome:R-HSA-74742 (Phosphorylation of SHC1)
- Reactome:R-HSA-8950423 (JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated)
- Reactome:R-HSA-8950757 (IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated)
- Reactome:R-HSA-8987202 (IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2)
- Reactome:R-HSA-8987150 (IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3)
- Reactome:R-HSA-8986994 (IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2)
- Reactome:R-HSA-8987084 (IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1)
- Reactome:R-HSA-8987141 (IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3)
- Reactome:R-HSA-8982163 (IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3)
- Reactome:R-HSA-8950537 (JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated)
- Reactome:R-HSA-8987042 (IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2)
- Reactome:R-HSA-177933 (SHC1 phosphorylation by phosphorylated EGFR)
- Reactome:R-HSA-8950269 (STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor)
- Reactome:R-HSA-8950405 (JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated)
- Reactome:R-HSA-166544 (TrkA receptor autophosphorylates)
- Reactome:R-HSA-167683 (TrkA phosphorylates PLCG1)
- Reactome:R-HSA-8983300 (IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1)
- Reactome:R-HSA-8983371 (IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5)
- Reactome:R-HSA-74711 (Phosphorylation of IRS)
- Reactome:R-HSA-8987070 (IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3)
- Reactome:R-HSA-8950485 (STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction)
- Reactome:R-HSA-8987096 (IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3)
- Reactome:R-HSA-8987129 (JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated)
- Reactome:R-HSA-8986995 (IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA)
- Reactome:R-HSA-8986985 (IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5)
- Reactome:R-HSA-8983424 (IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2)
- Reactome:R-HSA-74715 (Autophosphorylation of insulin receptor)
- Reactome:R-HSA-167019 (SHC, complexed with TrkA, is tyrosine-phosphorylated)
- Reactome:R-HSA-169905 (ARMS is phosphorylated by active TrkA receptor)
- Reactome:R-HSA-8987179 (IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3)
- Reactome:R-HSA-8983309 (IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1)
- Reactome:R-HSA-8950364 (IL23R in IL23:IL23 receptor complex is phosphorylated)
- Reactome:R-HSA-8987012 (IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1)
- MetaCyc:2.7.10.1-RXN
- Reactome:R-HSA-8853792 (RET tyrosine phosphorylation)
- Reactome:R-HSA-8987040 (IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1)
- Reactome:R-HSA-8950453 (JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4)
- EC:2.7.10.1 (skos:exactMatch)
- Reactome:R-HSA-8950354 (STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction)
- Reactome:R-HSA-8852552 (MST1R autophosphorylates)
- Reactome:R-HSA-8987255 (IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3)
- Reactome:R-HSA-6784324 (p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA)
- Reactome:R-HSA-8950340 (IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation)
receptor protein tyrosine kinase activity, receptor protein-tyrosine kinase activity
molecular_function
GO:0004714