The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded. [ http://www.ncbi.nlm.nih.gov/pubmed/15798367 http://www.ncbi.nlm.nih.gov/pubmed/16973210 http://www.ncbi.nlm.nih.gov/pubmed/20159618 http://www.ncbi.nlm.nih.gov/pubmed/12914914 http://www.ncbi.nlm.nih.gov/pubmed/9412464 http://www.ncbi.nlm.nih.gov/pubmed/11099404 ]