cargo receptor activity
http://purl.obolibrary.org/obo/GO_0038024
Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles. [ http://www.ncbi.nlm.nih.gov/pubmed/27903609 http://www.ncbi.nlm.nih.gov/pubmed/15239958 ]
Term info
- Reactome:R-HSA-350168 (LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D)
- Reactome:R-HSA-3000122 (CD320 transports extracellular TCII:Cbl to endosome)
goslim_generic, goslim_drosophila
Notes: (1) this term and its child terms are intended for receptors that bind to and internalize molecules by receptor-mediated endocytosis. For receptors that are coupled to a signal transduction pathway, consider instead the term 'signaling receptor activity ; GO:0038023' and its children. (2) Cargo receptors transport substances by vesicular transport, not by transmembrane transport. For transmembrane transporters, consider instead the term 'transmembrane transporter activity ; GO:0022857.
bf
2011-08-01T02:50:45Z
transport receptor activity, receptor activity
endocytic receptor activity, receptor activity involved in receptor-mediated endocytosis
molecular_function
GO:0038024