Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals. [ GOC:mtg_muscle http://www.ncbi.nlm.nih.gov/pubmed/11181628 http://www.ncbi.nlm.nih.gov/pubmed/11449884 http://www.ncbi.nlm.nih.gov/pubmed/12605307 ]