JSON

mature conventional dendritic cell differentiation

^ http://purl.obolibrary.org/obo/GO_0097029


The process in which antigen-activated dendritic cells acquire the specialized features of a mature conventional dendritic cell. Mature conventional dendritic cells upregulate the surface expression of MHC molecules, chemokine receptors and adhesion molecules, and increase the number of dendrites (cytoplasmic protrusions) in preparation for migration to lymphoid organs where they present antigen to T cells. [ GOC:BHF http://www.rndsystems.com/mini_review_detail_objectname_MR02_DendriticCellMat.aspx http://www.ncbi.nlm.nih.gov/pubmed/15845453 ]

Term info

comment

Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'.

creation date

2011-04-01T10:10:22Z

has obo namespace

biological_process

id

GO:0097029