JSON

Aganglionic megacolon

^ http://purl.obolibrary.org/obo/HP_0002251

An abnormality resulting from a lack of intestinal ganglion cells (i.e., an aganglionic section of bowel) that results in bowel obstruction with enlargement of the colon. [ PMID:17965226 HPO:probinson ]

Term info

database cross reference
  • SNOMEDCT_US:204739008
  • SNOMEDCT_US:33995003
  • UMLS:C0025160
  • SNOMEDCT_US:367495003
  • UMLS:C0019569
  • MSH:D008531
  • MSH:D006627
  • MEDDRA:10027110 (Megacolon)
Subsets

hposlim_core

comment

Aganglionic megacolon is characterized by congenital absence of intrinsic ganglion cells in the myenteric (Auerbach) and submucosal (Meissner) plexuses of the gastrointestinal tract.

definition

An abnormality resulting from a lack of intestinal ganglion cells (i.e., an aganglionic section of bowel) that results in bowel obstruction with enlargement of the colon.

has alternative id

HP:0002606, HP:0002030, HP:0004391, HP:0002029

has exact synonym

Hirschsprung megacolon, Congenital megacolon, Megacolon, Enlarged colon lacking nerve cells

has related synonym

Hirschsprung disease

id

HP:0002251

Term relations