Chromosome breakage
http://purl.obolibrary.org/obo/HP_0040012
Elevated rate of chromosomal breakage or interchanges occurring either spontaneously or following exposure to various DNA-damaging agents. This feature may be assayed by treatment of cultured lymphocytes with agents such as chemical mutagens, irradiation, and alkylating agents. [ PMID:12407692 HPO:probinson ]
Term info
- UMLS:C0376628
- MSH:D019457
HPO:skoehler
Elevated rate of chromosomal breakage or interchanges occurring either spontaneously or following exposure to various DNA-damaging agents. This feature may be assayed by treatment of cultured lymphocytes with agents such as chemical mutagens, irradiation, and alkylating agents.
High frequency of chromosome breaks in lymphocytes, Increased chromosomal breakage, Tendency to chromosomal breakage, Increased chromosomal breakage rate, Multiple chromosomal breaks