JSON

Neural tube defect

^ http://purl.obolibrary.org/obo/HP_0045005

A neural tube defect arises when the neural tube, the embryonic precursor of the brain and spinal cord, fails to close during neurulation. The cranial region (anencephaly) or the low spine (open spina bifida; myelomeningocele) are most commonly affected although, in the severe NTD craniorachischisis, almost the entire neural tube remains open, from midbrain to low spine. [ HPO:probinson PMID:19808787 ]

Term info

database cross reference
  • UMLS:C0027794
  • SNOMEDCT_US:253098009
  • MSH:D009436
created by

HPO:skoehler

definition

A neural tube defect arises when the neural tube, the embryonic precursor of the brain and spinal cord, fails to close during neurulation. The cranial region (anencephaly) or the low spine (open spina bifida; myelomeningocele) are most commonly affected although, in the severe NTD craniorachischisis, almost the entire neural tube remains open, from midbrain to low spine.

has exact synonym

Abnormality of neural tube closure

Term relations