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keratoacanthoma

^ http://purl.obolibrary.org/obo/MONDO_0002527

A dome-shaped, rapidly growing skin lesion composed of well differentiated squamous cells. It represents a proliferation of the infundibular epithelium of the hair follicle and its morphologic distinction from a well differentiated carcinoma may be difficult or impossible. Keratoacanthomas affect males more frequently than females and the majority tend to regress spontaneously. It has been suggested that keratoacanthoma represents a distinct subtype of squamous cell carcinoma of the skin. [ NCIT:C3146 ]

Term info

database cross reference
  • SCTID:254662007 (MONDO:equivalentTo)
  • UMLS:C0022572 (NCIT:C3146)
  • MESH:D007636 (MONDO:equivalentTo)
  • NCIT:C3146 (MONDO:exact-label-match)
  • DOID:3149 (MONDO:equivalentTo)
  • ICDO:8071/1 (NCIT:C3146)
comment

Clinically and histologically, it may be confused with a de novo highly malignant squamous cell carcinoma (SCC). However, KA may be viewed as an abortive cancer that only rarely progresses into an aggressive SCC - PMID:8277007.

definition

A dome-shaped, rapidly growing skin lesion composed of well differentiated squamous cells. It represents a proliferation of the infundibular epithelium of the hair follicle and its morphologic distinction from a well differentiated carcinoma may be difficult or impossible. Keratoacanthomas affect males more frequently than females and the majority tend to regress spontaneously. It has been suggested that keratoacanthoma represents a distinct subtype of squamous cell carcinoma of the skin.

exactMatch

http://purl.obolibrary.org/obo/DOID_3149, http://linkedlifedata.com/resource/umls/id/C0022572, http://identifiers.org/mesh/D007636, http://purl.obolibrary.org/obo/NCIT_C3146, http://identifiers.org/snomedct/254662007

excluded subClassOf

http://purl.obolibrary.org/obo/MONDO_0002529

id

MONDO:0002527