JSON

neuroblastoma

^ http://purl.obolibrary.org/obo/MONDO_0005072

Neuroblastoma (NB) is the most common solid, extracranial childhood tumor. It is an aggressive pediatric cancer that originates from neural crest tissues of the sympathetic nervous system. [ PMID:32903387 ]

Term info

database cross reference
  • DOID:769 (MONDO:equivalentTo)
  • SCTID:432328008 (MONDO:equivalentTo)
  • ONCOTREE:NBL (MONDO:equivalentTo)
  • MedDRA:10029260 (Orphanet:635/e)
  • NCIT:C3270 (MONDO:equivalentTo)
  • ICDO:9500/3 (NCIT:C3270)
  • UMLS:C0027819 (Orphanet:635/e)
  • EFO:0000621 (MONDO:equivalentTo)
  • NIFSTD:birnlex_12631 (EFO:0000621)
  • UMLS:CN205405 (MONDO:equivalentTo)
  • GARD:0007185 (MONDO:equivalentTo)
  • MESH:D009447 (Orphanet:635/e)
  • Orphanet:635 (MONDO:equivalentTo)
Subsets

gard_rare, ordo_disease

abbreviation
NB [ GARD:0007185 ]

closeMatch

http://identifiers.org/meddra/10029260

comment

NB is a disease of the sympaticoadrenal lineage of the neural crest, with tumors forming anywhere in the sympathetic nervous system. The tumors most commonly arise in the abdomen (65%), however, they also occur in the neck, chest, and pelvis. Approximately 50% of patients present with evidence of metastasis. Frequent metastasis sites include cortical bone, bone marrow, liver, and lymph nodes. The most common genetic change is MYCN amplification, which occurs in approximately 20% of patients, and is strongly correlated with advanced stage NB. Additionally, deletions of the short arm of chromosome 1 (1p) are found in 25–35% of patients and can be correlated with MYCN amplification. Outside of MYC linked changes, allelic loss of 11q is present in 35–45% of patients and is also associated with high-risk disease features.

definition

Neuroblastoma (NB) is the most common solid, extracranial childhood tumor. It is an aggressive pediatric cancer that originates from neural crest tissues of the sympathetic nervous system.

exactMatch

http://purl.obolibrary.org/obo/DOID_769, http://linkedlifedata.com/resource/umls/id/CN205405, http://identifiers.org/mesh/D009447, http://linkedlifedata.com/resource/umls/id/C0027819, http://purl.obolibrary.org/obo/NCIT_C3270, http://purl.obolibrary.org/obo/Orphanet_635, http://identifiers.org/snomedct/432328008

excluded subClassOf

http://purl.obolibrary.org/obo/MONDO_0016713, http://purl.obolibrary.org/obo/MONDO_0002366

has exact synonym

neuroblastoma (Schwannian Stroma-poor), neuroblastoma, neuroblastoma, malignant, neural Crest tumor, malignant

id

MONDO:0005072

seeAlso

https://rarediseases.info.nih.gov/diseases/7185/neuroblastoma