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carcinoid tumor

^ http://purl.obolibrary.org/obo/MONDO_0005369


A slow growing neuroendocrine tumor, composed of uniform, round, or polygonal cells having monotonous, centrally located nuclei and small nucleoli, infrequent mitoses, and no necrosis. The tumor may show a variety of patterns, such as solid, trabecular, and acinar. Electron microscopy shows small secretory granules. Immunohistochemical studies reveal NSE, as well as chromogranin immunoreactivity. Malignant histology (cellular pleomorphism, hyperchromatic nuclei, prominent nucleoli, necrosis, and mitoses) can occasionally be seen. Such cases may have an aggressive clinical course. Gastrointestinal tract and lung are common sites of involvement. [ NCIT:C2915 ]

Term info

database cross reference
  • EFO:0004243 (MONDO:equivalentTo)
  • ICD9:209.60 (MONDO:i2s)
  • SCTID:443492008 (MONDO:equivalentTo)
  • ICDO:8240/3 (NCIT:C2915)
  • NCIT:C2915 (MONDO:equivalentTo)
  • MESH:D002276 (MONDO:equivalentTo)
  • GARD:0009316 (MONDO:shared-umls-xref)
  • ICDO:8241/3 (NCIT:C2915)
  • HP:0100570 (MONDO:otherHierarchy)
IAO 0000589

carcinoid tumor (disease)

comment

Editor note: In NCIT all carcinoid tumors are grade 1, but the name is sometimes used more broadly in other sources

definition

A slow growing neuroendocrine tumor, composed of uniform, round, or polygonal cells having monotonous, centrally located nuclei and small nucleoli, infrequent mitoses, and no necrosis. The tumor may show a variety of patterns, such as solid, trabecular, and acinar. Electron microscopy shows small secretory granules. Immunohistochemical studies reveal NSE, as well as chromogranin immunoreactivity. Malignant histology (cellular pleomorphism, hyperchromatic nuclei, prominent nucleoli, necrosis, and mitoses) can occasionally be seen. Such cases may have an aggressive clinical course. Gastrointestinal tract and lung are common sites of involvement.

exactMatch

http://purl.obolibrary.org/obo/NCIT_C2915, http://identifiers.org/mesh/D002276, http://identifiers.org/snomedct/443492008

has exact synonym

NET G1, carcinoid tumor, neuroendocrine tumor G1, neuroendocrine neoplasm G1, carcinoid, carcinoid tumor (disease)

id

MONDO:0005369