chronic myelogenous leukemia, BCR-ABL1 positive
http://purl.obolibrary.org/obo/MONDO_0011996
A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors delay disease progression and prolong overall survival. [ NCIT:C3174 ]
Term info
- ICDO:9875/3 (NCIT:C3174)
- ICDO:9863/3 (NCIT:C3174)
- DOID:0081088 (MONDO:equivalentTo)
- ONCOTREE:CML (MONDO:equivalentTo)
- ICD9:205.1 (EFO:0000339)
- OMIM:608232 (Orphanet:521/e)
- NCIT:C3177 (MONDO:directSiblingOf)
- GARD:0006105 (MONDO:equivalentTo)
- NCIT:C3174 (MONDO:equivalentTo)
- EFO:0000339 (MONDO:equivalentTo)
- DOID:8552 (MONDO:equivalentTo)
- Orphanet:521 (OMIM:608232)
- UMLS:C0023473 (Orphanet:521/e)
- MedDRA:10009013 (Orphanet:521/e)
ordo_disease
https://github.com/monarch-initiative/mondo/issues/4521
http://identifiers.org/meddra/10009013
A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors delay disease progression and prolong overall survival.
http://linkedlifedata.com/resource/umls/id/C0023473, http://purl.obolibrary.org/obo/Orphanet_521, https://omim.org/entry/608232, http://purl.obolibrary.org/obo/DOID_8552, http://purl.obolibrary.org/obo/DOID_0081088, http://purl.obolibrary.org/obo/NCIT_C3174
hematopoeitic - chronic myelocytic leukemia (CML), CML, leukemia, Philadelphia chromosome-positive, resistant to imatinib, Somatic mutation, BCR-ABL Positive chronic myelogenous leukemia, chronic granulocytic leukemia, myeloid leukemia, chronic, chronic myelogenous leukemia, chronic myelocytic leukemia, leukemia, chronic myeloid, Philadelphia chromosome positive, somatic, CML - chronic myelogenous leukemia, chronic myelogenous leukemia (CML), chronic myelogenous leukemia, BCR-ABL1 Positive, chronic myeloid leukemia, chronic myelogenous leukemias
leukemia, chronic myeloid, atypical, leukemia, chronic myelogenous, leukemia, chronic myeloid
MONDO:0011996