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agammaglobulinemia

^ http://purl.obolibrary.org/obo/MONDO_0015977

A decreased level of serum immunoglobulins. It may be inherited or acquired. It is caused by decreased or inefficient production of immunoglobulins from B cells or by a decrease in the numbers of B cells themselves. Low levels of immunoglobulins will affect the immune system's ability to combat bacterial infection. Supplementation of immunoglobulins is needed to prevent worsening outcomes. [ NCIT:P378 ]

Term info

database cross reference
  • OMIMPS:601495 (MONDO:equivalentTo)
  • Orphanet:183669 (MONDO:equivalentTo)
  • ICD9:279.00 (DOID:2583)
  • MESH:D000361 (Orphanet:183669/e)
  • GARD:0007455 (MONDO:equivalentTo)
  • DOID:2583 (MONDO:equivalentTo)
  • MedDRA:10001471 (Orphanet:183669/e)
Subsets

gard_rare, disease_grouping, ordo_group_of_disorders

abbreviation
IGHM [ DOID:2583 ]

closeMatch

http://identifiers.org/meddra/10001471

definition

A decreased level of serum immunoglobulins. It may be inherited or acquired. It is caused by decreased or inefficient production of immunoglobulins from B cells or by a decrease in the numbers of B cells themselves. Low levels of immunoglobulins will affect the immune system's ability to combat bacterial infection. Supplementation of immunoglobulins is needed to prevent worsening outcomes.

exactMatch

http://identifiers.org/mesh/D000361, http://purl.obolibrary.org/obo/Orphanet_183669, https://omim.org/phenotypicSeries/PS601495, http://purl.obolibrary.org/obo/DOID_2583

has exact synonym

IGHM, agammaglobulinemia, mu heavy chain deficiency, hypogammaglobulinemia

has related synonym

Immunoglobulin Deficiency, Gammaglobulin Deficiency, antibody Deficiency

id

MONDO:0015977