glioblastoma
http://purl.obolibrary.org/obo/MONDO_0018177
The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO) [ NCIT:C3058 ]
Term info
- Orphanet:360 (MONDO:equivalentTo)
- HP:0012174 (MONDO:otherHierarchy)
- MedDRA:10018336 (Orphanet:360/e)
- EFO:0000519 (https://orcid.org/0000-0002-9584-9618)
- DOID:3068 (MONDO:equivalentTo)
- MESH:D005909 (https://orcid.org/0000-0003-1967-3726)
- GARD:0002491 (MONDO:equivalentTo)
- UMLS:C1621958 (Orphanet:360/e)
- ONCOTREE:GB (MONDO:equivalentTo)
- NCIT:C3058 (MONDO:equivalentTo)
- HP:0100843 (MONDO:otherHierarchy)
- UMLS:CN227279 (MONDO:equivalentTo)
- SCTID:393563007 (MONDO:equivalentTo)
- ONCOTREE:GBM (MONDO:equivalentTo)
- MedDRA:10018337 (Orphanet:360/e)
- UMLS:C0017636 (Orphanet:360/e)
- ICDO:9440/3 (NCIT:C3058)
ordo_disease
https://github.com/monarch-initiative/mondo/issues/5798
glioblastoma (disease)
http://identifiers.org/meddra/10018336, http://identifiers.org/meddra/10018337
The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO)
http://linkedlifedata.com/resource/umls/id/C0017636, http://purl.obolibrary.org/obo/NCIT_C3058, http://purl.obolibrary.org/obo/DOID_3068, http://identifiers.org/snomedct/393563007, http://linkedlifedata.com/resource/umls/id/C1621958, http://identifiers.org/mesh/D005909, http://purl.obolibrary.org/obo/Orphanet_360, http://linkedlifedata.com/resource/umls/id/CN227279
glioblastoma multiforme, glioblastoma, GBM, grade IV astrocytic tumor, grade IV astrocytic neoplasm, glioblastoma multiforme (disease), grade IV astrocytoma, spongioblastoma multiforme, primary glioblastoma multiforme, glioblastoma (disease), WHO grade IV glioma, GBM (glioblastoma)
grade IV adult astrocytic tumor
giant cell glioblastoma (histologic variant), gliosarcoma (histologic variant)
MONDO:0018177